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Scientists have figured out the role of aspirin in the prevention of COVID-19


Israeli scientists have found that aspirin, an inexpensive and safe drug, reduces the likelihood of contracting COVID-19. The results of the study are published in the FEBS Journal.
It is known that aspirin is a common drug that is often prescribed for the prevention and treatment of cardiovascular diseases, as well as an analgesic and antipyretic agent, can modulate innate and adaptive immune responses, helping the human immune system to fight off certain viral infections. It was widely used during the Spanish flu pandemic in 1918, and later scientists confirmed its activity against RNA viruses in vitro.
Researchers from Israel's Leumit Health Services, Bar-Ilan University and Barzilai Medical Center hypothesized that prophylactic low-dose aspirin - about 75 milligrams per day - could reduce susceptibility to coronavirus and ease the course of COVID-19 if infected.

Using data from the network of family medicine clinics Leumit Health Services and the National Organization for Health Maintenance, the authors analyzed the results of tests of 10,477 people who underwent PCR testing during the first wave of COVID-19 in Israel from February 1 to June 30, 2020. At the same time, a separate group was allocated to generally healthy people who took aspirin to prevent cardiovascular diseases.
It turned out that the use of aspirin reduced the likelihood of contracting coronavirus by 29 percent, and the duration of the disease in those who took aspirin was 2-3 days shorter. Among those hospitalized with the coronavirus, the death rate was also lower in the group of people taking aspirin: 14 percent versus 19 percent in the control group.

"We found that aspirin is clearly a protective factor. The drug affects both duration and severity of illness and even mortality," co-author Dr. Ilan Green said in a press release from Bar-Ilan University. from Leumit Health Services - Even in the age of vaccines, this is still important. First, because not the entire population is vaccinated. Second, the vaccine does not work immediately, but after a period of time. And besides, the vaccine is not 100 percent. effective. Protection is 95 percent, and aspirin can be another way to protect yourself. "
The authors note that their observational epidemiological study is preliminary and they did not aim to elucidate the biological mechanisms of action of aspirin on the coronavirus. At the same time, scientists believe that the faster recovery from COVID-19 harm to those who took aspirin is due to the anti-inflammatory properties of the drug.
"This observation of the beneficial effects of low-dose aspirin on COVID-19 infection is preliminary but seems very promising," said Professor Eli Magen of Barzilai Medical Center, who led the study.
"This study was aimed at better understanding the potential beneficial effects of aspirin on the human immune system in the fight against COVID-19," adds another study participant, Dr Milana Frenkel-Morgenstern of Bar University School of Medicine. -Ilana.
The authors emphasize the need to continue studies using larger randomized clinical samples and include patients from other hospitals and countries to verify the results, and also caution against self-administration of the drug without prior consultation with the attending physician.

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